Viscerotropic potential of parasites isolated from post-kala-azar dermal leishmaniasis cases: an experimental evidence.
نویسندگان
چکیده
منابع مشابه
DNA polymorphism assay distinguishes isolates of Leishmania donovani that cause kala-azar from those that cause post-kala-azar dermal Leishmaniasis in humans.
Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.
متن کاملPost kala-azar dermal leishmaniasis: macular variety.
A 7-year-old boy presented with numerous asymptomatic whitish flat lesions of varying sizes over the whole body for last two years. Patient was diagnosed as kala-azar about 3 years previously, and was treated suboptimally. There was no other systemic complaints like fever, pain abdomen or photosensitivity. On examination, there were asymptomatic hypopigmented macules and patches over the face (...
متن کاملPost-kala-azar dermal leishmaniasis in visceral leishmaniasis-endemic communities in Bihar, India.
We assessed the prevalence of post-kala-azar dermal leishmaniasis (PKDL), a late cutaneous manifestation of visceral leishmaniasis (VL), in 16 VL-endemic communities in Bihar, India. The prevalence of confirmed PKDL cases was 4.4 per 10 000 individuals and 7.8 if probable cases were also considered. The clinical history and treatment of the post-kala-azar dermal leishmaniasis cases are discussed.
متن کاملClinicopathological and Immunological Changes in Indian Post Kala-Azar Dermal Leishmaniasis (PKDL) Cases in relation to Treatment: A Retrospective Study
Post-kala-azar dermal leishmaniasis (PKDL) is an important factor in kala-azar transmission; hence its early detection and assessment of effective treatment is very important for disease control. In present study on 60 PKDL cases presented with macular, mixed papulonodular, or erythematous lesions, Leishmania parasites were demonstrated microscopically in 91% of papulonodular and 40% of macular...
متن کاملInfectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.
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ورودعنوان ژورنال:
- Journal of vector borne diseases
دوره 49 4 شماره
صفحات -
تاریخ انتشار 2012